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Table. 2.

Table. 2.

External proficiency testing programs

Program Test item website
Korean Association of External Quality Assessment Service(KAEQAS) Proficiency Testing http://eqas.keqas.org/
Newborn screening Basic & Extended newborn screening for inherited metabolic disorders
Amino acids Amino acid profile
Organic acids Organic acid profile
Special metabolites Catecholamines (plasma, urine)
Metanephrines (plasma, urine)
Methylmalonic acid
Vanillymandelic acid
Immunosuppressive drugs Cyclosporine, tacrolimus, sirolimus, everolimus, mycophenolic acid
College of American Pathologists (CAP) Proficiency Testing http://www.cap.org/
Vitamin D (VITD) 25-hydroxy vitamin D
Accuracy-Based Vitamin D (ABVD) 25-hydroxy vitamin D
Bone Markers and Vitamins (BMV) 1,25 dihydroxyvitamin D, vitamin A, vitamin E
CAP/AACC Immunosuppressive Drugs (CS) Cyclosporine, tacrlimus, sirolimus
Everolimus (EV) Everolimus
Mycophenolic acid (MPA) Mycophenolic acid
Therapeutic Drug Monitoring - Extended (ZE)
Clozapine, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine metaboltie, pregabalin, rufinamide, teriflunomide, topiramate, zonisamide
Therapeutic Drug Monitoring - Special (ZT) Amitriptyline, desipramine, imipramine, nortriptyline
Urine Chemistry - Special (NX) 3-methoxytyramines, 5-hydroxyindoleacetic acid (5-HIAA), 17-ketosteroids, dopamine, epinephrine, homovanillic acid (HVA), metanrphrine, norepineprine, normetanephrine, vanillylmandelic acid, cortisol, aldosterone
Accuracy-Based Testosterone, Estradiol (ABS) Cortisol, testosterone, estradiol
Salivary Cortisol (SALC)
Biochemical Genetics (BGL) Acylcarnitines, amino acids, carnitine, glycosaminoglycans, organic acids
Homocysteine (HMS) Homocysteine
Toxicology (T)
Urine Toxicology (UT)
CAP/AACC Urine Drug Testing, Screening (UDS)
CAP/AACC Forensic Urine Drug Testing, Confirmatory (UDC)
Oral Fluid for Drugs of Abuse (OFD)
Serum Drug Screening (SDS)
CAP/AACC Alcohol/Volatiles (AL) Acetone, ethanol, ethylene glycol, isopropanol, methanol
Ethanol Biomarkers (ETB) Ethyl glucuronide, ethyl sulfate
Nicotine and Tobacco Alkaloids (NTA) Anabasine, cotinine, nicotine
Centers for Disease Control and Prevention (CDC) Laboratory Quality Assurance and Standardization Programs https://www.cdc.gov/labstandards
Newborn Screening Quality Assurance Program (NSQAP) Amino acids, acylcarnitines and succinylacetone (SUAC)
Lysosomal storage disorder
2nd-tier Congenital adrenal hyperplasia, maple syrup urine disease (MSUD), methylmalonic/propionic acidemia and homocystinuria
Hormone Standardization Program (Host) Steroid hormones
Vitamin A Laboratory - External Quality Assurance (VITAL-EQA) Vitamin A
Vitamin D Standardization-Certification Program (VDSCP) 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D
LGC Standard Proficiency Testing https://www.lgcstandards.com/
Immunosuppressant (IPT) Cyclosporine, tacrolimus, sirolimus, everolimus, mycophenolic acid
Therapeutic Drugs (TDM) Antiepileptic drugs mixture, Cardiac drugs mixture, Analgesic mixture, Drugs for the treatment of substance related disorders 1 and 2, Psychoactive drugs, Smoking related drug, Immunosuppressive drugs
Therapeutic Drugs-Antibiotics (ANTIBIOTICS) Teicoplanin
Toxicology (TOX) Quantitative analysis:
- Blood (carboxyhemoglobin, ethanol, paracetamol and salicylic acid)
- Serum (ethanol, paracetamol and salicylic acid)
- Urine (gammahydroxybutyrate (GHB) and ethanol)
- Lyophilized serum samples for a range of drugs
Toxicology case studies:
- Human serum and urine test material accompanied by a clinical or forensic scenario requiring interpretation
Toxicology in blood: - Human blood for quantitative measurement of specified analytes (opiates, opioids, benzodiazepines, tricyclics, selective serotonin reuptake inhibitors (SSRIs), antipsychotics and other compounds that may be monitored in cases of drug overdose)
Toxic alcohols
- Acetone, ethanol, ethylene glycol, isopropanol (IPA), methanol
Drugs of Abuse in Hair (DAH)
Drugs of Abuse in Oral Fluid (DOF)
Drugs of Abuse in Urine (DAU)
Kwaliteitsbewaking Klinische Geneesmiddelanalyse en Toxicologie (KKGT) Quality Assessment http://kkgt.nl/
Alcohols/GHB Ethanol, ethylene glycol, GHB, methanol
Analgesic drugs Ibuprofen, paracetamol, salicylic acid
Anti-epileptic drugs Carbamazepine,carbamazepine-10,11-epoxide (CBZ-E), ethosuximide, phenobarbital, phenytoin, lamotrigine, levetiracetam, monohydroxycarbazepine, valproic acid
Antifungal drugs Fluconazole, itraconazole, hydroxyitraconazole, voriconazole, posaconazole, flucytosine
Antituberculosis drugs, Ethambutol, isoniazid, levofloxacin, linezolid, moxifloxacin, pyrazinamid, rifampicin
Antiviral drugs, Acyclovir, ganciclovir, ribavirin
Benzodiazepines Clobazam, desmethylclobazam, clonazepam, midazolam, 1-, and 4-hydroxymidazolam
Cardiac drugs, Amiodarone, desethylamiodarone, caffeine, digoxin, flecainide, theophylline
Psychotherapeutic drugs Amitriptyline, nortriptyline, clozapine, clomipramin, desmethylclomipramine, imipramine, desipramine, lithium, zuclopentixol, fluoxetine, desmethylfluoxetine, fluvoxamine, mirtazapine, desmethylmirtazapine, paroxetine, quetiapine, aripiprazol, citalopram, desmethylcitalopram, olanzapine, risperidone, hydroxyrisperidon, haloperidoll, sertraline, N-desmethylsertraline, venlafaxine, O-desmethylvenlafaxine
Thiopurines 6-thioguanine, 6-methylmercaptopurine
Drugs of Abuse Amphetamines, opiates, cannabinoids, cocaine, benzodiazepines, ethanol, methadone, barbiturates and other drugs
Toxicology
Various drugs Imatinib, Flucloxacilline, Infliximab, Adalimumab, Meropenem, Metoprotol, Warfarin, Acenocoumarol, etc.
Vitamin D External Quality Assessment Scheme (DEQAS) 25 hydroxyvitamin D and 1,25 dihydroxyvitamin D http://www.deqas.org/
German External Quality Assessment Scheme (G-EQAS) www.g-equas.de
tobacco-smoke related parameters cotinine, nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)
alcohols, ketones, ether and aromatic hydrocarbons
mercapturic acids
European Research Network for evaluation and improvement of screening, Diagnosis and treatment of Inherited disorders of Metabolism (ERNDIM) External Quality Assurance Scheme https://erndim.org/home/qascheme.asp
Acylcarnitines (ACS, ACDB) Acylcarnitines in dried blood spots/serum
Amino acids (QTAS, QTOU) Amino acid profile in serum/urine
Organic acids (QLOU) Organic acid profile in urine
Special assay in dried blood spots (SADB) Allo-isoleucine, homocystiene, isoleucine, leucine, methionine, phenylanalnine, succinylacetone, tyrosine, valine, free carnitine (C0)
The Royal College of Pathologists of Australia Quality Assurance Programs (RCPAQAP) https://rcpaqap.com.au/
Endocrine: Steroids Aldosterone, androstenedione, cortisol, dehydroepiandrosterone sulfate (DHEA-S), progesterone, testosterone, estradiol, vitamin D3, etc.
Qualitative & Quantitative Drug Testing
On-site Urine Toxicology Scrrening Amphetamines, benzodiazepines, cannabis metabolites, cocaine metabolites, opiates
Oral fluid Toxicology Screening Amphetamines, benzodiazepines, cannabis metabolites, cocaine metabolites, opiates
Plasma metanephrines Metanephrine, normetanephrine, 3-methoxythyramine
Biogenic amines Catecholamines, HVA, VMA, 5HIAA, metanephrines, serotonin
Immunosuppressants Cyclosporine, sirolimus
Special Drugs Amiodarone, clozapine, mycophenolate, methotrexate, tricyclic antidepressants, anti-fungals
Vitamins Vitamin A, E, B6, beta-carotene, total carotenoids, methylmalonic acid
Lab Med Online 2020;10:185~196 https://doi.org/10.3343/lmo.2020.10.3.185
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