Table. 5.
Parameters for panic checks
| AFP | CA125 | CA19-9 | CEA | PSA |
T3 | Free T4 | TSH | |
|---|---|---|---|---|---|---|---|---|
| Number of labs performing tests (%) | 84 (100.0) | 79 (100.0) | 82 (100.0) | 84 (100.0) | 85 (100.0) | 86 (100.0) | 86 (100.0) | 86 (100.0) |
| Number of labs performing panic checks (%) | 39 (46.4) | 37 (46.8) | 42 (51.2) | 42 (50.0) | 39 (45.9) | 32 (37.2) | 31 (36.0) | 34 (39.5) |
| Source for panic check criteria (number of labs (%)) | ||||||||
| In-house data (in-house settings) | 14 (35.9) | 13 (35.1) | 16 (38.1) | 15 (35.7) | 13 (33.3) | 12 (37.5) | 12 (38.7) | 13 (38.2) |
| Reagent company | 12 (30.8) | 10 (27.0) | 12 (28.6) | 14 (33.3) | 13 (33.3) | 8 (25.0) | 8 (25.8) | 9 (26.5) |
| Literature review | 4 (10.3) | 4 (10.8) | 4 (9.5) | 4 (9.5) | 4 (10.3) | 4 (12.5) | 3 (9.7) | 4 (11.8) |
| Consult with clinician | 2 (5.1) | 3 (8.1) | 3 (7.1) | 2 (4.8) | 2 (5.1) | 2 (6.3) | 2 (6.5) | 2 (5.9) |
| In-house data with literature review | 2 (5.1) | 2 (5.4) | 2 (4.8) | 2 (4.8) | 2 (5.1) | 2 (6.3) | 2 (6.5) | 2 (5.9) |
| Reagent company and literature review | 1 (2.6) | 1 (2.7) | 1 (2.4) | 1 (2.4) | 1 (2.6) | 0 | 0 | 0 |
| Others |
4 (10.3) | 4 (10.8) | 4 (9.5) | 4 (9.5) | 4 (10.3) | 4 (12.5) | 4 (12.9) | 4 (11.8) |
| Criteria for panic check | ||||||||
| Roche (units) | ng/mL | U/mL | U/mL | ng/mL | ng/mL | ng/mL | ng/dL | μIU/mL |
| panic check – low | No–0.9 | No–0.6 | No–2 | No–0.3 | No–0.1 | No–0.8 | No–0.93 | No-0.35 |
| panic check – high | 7–1,210 | 35–5,000 | 27–1,200 | 3.1–1,500 | 3–100 | 1.6–6.51 | 1.5–7.77 | 4.2–100 |
| reference interval | ≤ 7.0 | ≤ 35 | ≤ 34 | ≤ 4.3 | ≤ 1.4 | 0.8–2.0 | 0.93–1.70 | 0.27–4.2 |
| AMR | 0.908–1,210 | 0.6–5,000 | 0.6–1,000 | 0.2–1,000 | 0.003–100 | 0.195–6.51 | 0.23–7.77 | 0.005–100 |
| Abbott (units) | ng/mL | U/mL | U/mL | ng/mL | ng/mL | ng/mL | ng/dL | μIU/mL |
| panic check – low | No–0.1 | No–0.1 | No–0 | No–0.1 | No–0.1 | 0–0.57 | 0–0.7 | No-0.1 |
| panic check – high | 8.04–499 | 35–1,000 | 37–1,199 | 5–500 | 4–100 | 1.6–3.5 | 1.49–3.5 | 4.95–100 |
| reference interval | < 8.8 | ≤ 35 | ≤ 37 | ≤ 5.0 | ≤ 4.0 | 0.35–1.93 | 0.7–1.48 | 0.35–4.94 |
| AMR | 2.0–2,000 | 1.0–1,000 | 2.0–1,200 | 0.5–1,500 | 0.008–100 | 0.35–8.0 | 0.4–6.0 | 0.01–100 |
| Siemens (units) | ng/mL | U/mL | U/mL | ng/mL | ng/mL | ng/mL | ng/dL | μIU/mL |
| panic check – low | No–1.5 | No–3.1 | No–4 | No–0.57 | No–0.03 | 0.241–0.6 | 0.34–0.89 | No-0.1 |
| panic check – high | 25–1,209 | 30.2–4,999 | 37–1,000 | 5–130 | 4–100 | 1.81–6.394 | 1.76–4.3 | 5.5–135.5 |
| reference interval | ≤ 8.0 | ≤ 30.2 | ≤ 37 | ≤ 5.0 | ≤ 4.0 | 0.60–1.81 | 0.89–1.76 | 0.55–4.78 |
| AMR | 1.3–1,000 | 2.0–600 | 1.2–700 | 0.5–100 | 0.01–100 | 0.1–8 | 0.1–12 | 0.008–150 |
| Beckman Coulter (units) | ng/mL | U/mL | U/mL | ng/mL | ng/mL | ng/mL | ng/dL | μIU/mL |
| panic check – low | 0 | No | No | No | No-0.1 | 0.4 | No | No |
| panic check – high | 9 | 35 | 35 | 5 | 4–49 | 3 | 4 | 50 |
| reference interval | 0–9 | 0–35 | 0–35 | 0–5 | 0–4 | 0.87–1.78 | 0.58–1.64 | 0.38–5.33 |
| AMR | 0.5–3,000 | 0.5–5,000 | 0.8–2,000 | 0.1–1,000 | 0.008–150 | 0.1–8 | 0.25–6 | 0.005–50 |
| Ortho clinical diagnostics (units) | ||||||||
| panic check – low | - | No | No | No | No | - | - | - |
| panic check – high | - | 50 | 50 | 20 | 20 | - | - | - |
| reference interval | - | - | - | - | - | - | - | - |
| AMR | 0.5–500 | 5.5–1,000 | 1.4–1,000 | 0.31–400 | 0.01–100 | - | - | - |
The reference intervals and AMR of each assay were based on data provided by the reagent company.
*Others include unknown source, previously used set, application of the upper limit of the reference interval +50%.
†Reference intervals of PSA were based on patients aged <40 years.
Abbreviations: AFP, alpha-fetoprotein; AMR, analytical measurement range; CA125, cancer antigen 125; CA19-9, cancer antigen 19-9; CEA, carcinoembryonic antigen; Labs, laboratories; No, no setting value; PSA, prostate-specific antigen; TSH, thyroid-stimulating hormone; T3, triiodothyronine; T4, thyroxine.
Lab Med Online 2023;13:324~331 https://doi.org/10.47429/lmo.2023.13.4.324
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