Fig. 6. The relationship between AMI, EMI, and RI. For example, if a measurement procedure has performance characteristics of LLoD=1 ng/mL, LLoQ=2 ng/mL, ULoQ=10 ng/mL, and a maximally recommended dilution factor of 5, the AMI is 2-10 ng/mL, the EMI is 10-50 ng/mL, and the RI is 1-100 ng/mL. (Reprinted with permission from Clinical and Laboratory Standards Institute from: CLSI. Establishing and Verifying an Extended Measuring Interval Through Specimen Dilution and Spiking. 1st ed. CLSI guideline EP34. Wayne, PA: Clinical and Laboratory Standards Institute, 2018 [19]).
Abbreviations: AMI, analytical measuring interval; EMI, extended measuring interval; RI, reportable interval; LLoD, lower limit of detection; LLoQ, lower limit of quantitation; ULoQ, upper limit of quantitation.

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